Rinpoche was born in the Himalayan Mountains and entered Tashi Gomang Monastery at a young age. He was recognized as the reincarnation of Padma Rangdrol Dorje Rinpoche, the former Dharma Master of the Sacred Site of Tashi Gomang, by many enlightened beings, including Dakini Kunzang Chokyi Drolma, Tartang Garlong Rinpoche, and Zabtrul Shindu Rinpoche. Guidance from his teacher Tarthong Garlong Rinpoche led Tulku Orgyen to Sertar Larung Gar Buddhist Institute, where he began 15 years of intensive study under his heart teacher, His Holiness Khenpo Jigme Phuntsok, one of the most revered Buddhist saints of our age.

During his time with H.H. Khenpo Jigme Phuntsok, Tulku Orgyen's training included Buddha Shakyamuni's Mahayana Sutra Teachings and Commentary, including the sutra commentaries of Nagarjuna, Shantideva, and Shantarakshita. He also recieved Buddha Shakyamuni's Vajrayana Tradition through Padmasambhava, and the entire cycle of teachings from Guru Rinpoche (Padmasambhava), Kunkyen Longchen Rinpoche, Jigme Lingpa Rinpoche, Jamyang Khentse Wangpo Rinpoche, Patrul Rinpoche, Shabkar Rinpoche, Lama Mipham Rinpoche, and Khenpo Jigme Phuntsok Rinpoche. After recieving these transmissions, teachings, and empowerments he practiced and studied for many years. He then traveled to Lhasa to Shindu Monastery to give teachings and empowerments. Zabtrul Shindu Rinpoche then gave the title of head of the monastery to Tulku Orgyen Zangpo Rinpoche.

Subsequently, the current head of Tartang Monastery Lhatrul Orgyen Garwang Nyima Rinpoche well as many heads of monastaries, tulkus, khenpos, and monks installed Tulku Orgyen Zangpo Rinpoche as the head of Tashi Gomang Monastery as part of a very special ceremony bestowing upon him the title of Spiritual Head of Tashi Gomang

Tulku Orgyen Zangpo has dedicated his life to maintaining not only the legacy of Tashi Gomang Monastery and its humble meditation community, but also to the numerous other monasteries that have been entrusted to him, and to enriching and assuring their survival in the centuries to come. Through his Compassion Fellowship, he hopes to establish a temple for practitioners which can serve as a focus for dharma studies, teachings and retreats.